Issue 10, 2017

Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Abstract

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Graphical abstract: Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Supplementary files

Article information

Article type
Communication
Submitted
04 Nov 2016
Accepted
05 Jan 2017
First published
05 Jan 2017

Chem. Commun., 2017,53, 1607-1610

Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

S. Lim, Md. M. Haque, D. Su, D. Kim, J. Lee, Y. Chang and Y. K. Kim, Chem. Commun., 2017, 53, 1607 DOI: 10.1039/C6CC08826K

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