A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

Shahi Imam Reja; Muskan Gupta; Neha Gupta; Vandana Bhalla; Puja Ohri; Gurcharan Kaur; Manoj Kumar

doi:10.1039/C6CC09127J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells†

Shahi Imam Reja,‡^a Muskan Gupta,‡^b Neha Gupta,^a Vandana Bhalla,

^a Puja Ohri,^c Gurcharan Kaur*^b and Manoj Kumar*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India
E-mail: mksharmaa@yahoo.co.in

^b Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, India

^c Department of Zoology, Guru Nanak Dev University, India

Abstract

A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H₂O₂) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H₂O₂ in living cell lines.

This article is part of the themed collections: Biological optical imaging and Most downloaded articles of 2017: Analytical Chemistry

Download options Please wait...

Supplementary files

Supplementary information PDF (1320K)

Article information

DOI: https://doi.org/10.1039/C6CC09127J
Article type: Communication
Submitted: 25 Nov 2016
Accepted: 27 Feb 2017
First published: 01 Mar 2017

Download Citation

Chem. Commun., 2017,53, 3701-3704

Permissions

Request permissions

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

S. I. Reja, M. Gupta, N. Gupta, V. Bhalla, P. Ohri, G. Kaur and M. Kumar, Chem. Commun., 2017, 53, 3701 DOI: 10.1039/C6CC09127J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

Social activity

Search articles by author

Spotlight

Advertisements