Metal–organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging

Abstract

We have demonstrated the ability of iron carboxylate metal–organic frameworks to efficiently deliver unmethylated cytosine–phosphate–guanine oligonucleotides. The nanoconjugates induced a stronger immune response than did free cytosine–phosphateguanine oligonucleotides and showed T₂-magnetic resonance imaging ability both in vitro and in vivo.