Issue 5, 2017

An easily accessible aggregation-induced emission probe for lipid droplet-specific imaging and movement tracking

Abstract

Lipid droplets (LDs) as dynamic organelles are associated with many metabolic processes. Ideal fluorescent probes for LD-specific imaging require excellent specificity, superior brightness, fast cell permeability, and easy preparation. However, conventional fluorophores for LD imaging suffer from drawbacks of aggregation-caused quenching (ACQ), poor photostability, and difficulty of preparation. To tackle these challenges, herein, we develop an easily accessible aggregation-induced emission (AIE) fluorescent probe for LD-specific imaging and dynamic movement tracking. This AIE probe has significant advantages in terms of fast cell permeability, low cytotoxicity, strong photostability, and high two-photon absorption cross-sections in the near infra-red (NIR) range. It is thus expected to have broad applications in the study of LDs' biological functions.

Graphical abstract: An easily accessible aggregation-induced emission probe for lipid droplet-specific imaging and movement tracking

Supplementary files

Article information

Article type
Communication
Submitted
28 Nov 2016
Accepted
15 Dec 2016
First published
23 Dec 2016

Chem. Commun., 2017,53, 921-924

An easily accessible aggregation-induced emission probe for lipid droplet-specific imaging and movement tracking

M. Gao, H. Su, S. Li, Y. Lin, X. Ling, A. Qin and B. Z. Tang, Chem. Commun., 2017, 53, 921 DOI: 10.1039/C6CC09471F

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