Cp*Rh(III)-catalyzed C(sp3)–H alkylation of 8-methylquinolines in aqueous media

Saegun Kim; Sangil Han; Jihye Park; Satyasheel Sharma; Neeraj Kumar Mishra; Hyunjung Oh; Jong Hwan Kwak; In Su Kim

doi:10.1039/C6CC09830D

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Cp*Rh(iii)-catalyzed C(sp³)–H alkylation of 8-methylquinolines in aqueous media†

Saegun Kim,‡^a Sangil Han,‡^a Jihye Park,^a Satyasheel Sharma,^a Neeraj Kumar Mishra,^a Hyunjung Oh,^a Jong Hwan Kwak^a and In Su Kim

*^a

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* Corresponding authors

^a School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

The rhodium(III)-catalyzed cross-coupling reaction of 8-methylquinolines with a range of allylic alcohols in water is described. This approach leads to the synthesis of various γ-quinolinyl carbonyl compounds, which are synthetically useful precursors for the construction of bioactive tetrahydroquinoline and azasteroid derivatives.

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Article information

DOI: https://doi.org/10.1039/C6CC09830D
Article type: Communication
Submitted: 10 Dec 2016
Accepted: 30 Jan 2017
First published: 30 Jan 2017

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Chem. Commun., 2017,53, 3006-3009

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Cp*Rh(III)-catalyzed C(sp³)–H alkylation of 8-methylquinolines in aqueous media

S. Kim, S. Han, J. Park, S. Sharma, N. K. Mishra, H. Oh, J. H. Kwak and I. S. Kim, Chem. Commun., 2017, 53, 3006 DOI: 10.1039/C6CC09830D

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Chemical Communications