Issue 12, 2017

Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(iii) complexes

Abstract

Herein a series of mitochondria-targeted AIE (aggregation-induced emission)-active Ir(III) complexes were designed to selectively exert one-/two-photon photodynamic activities in mitochondria to address the issues which current PDT are confronted with (i.e., shallow penetration depth of routinely used irradiation; systematic toxicity associated with effective drug concentration; concentration-quenched photodynamic activity at the target, etc.).

Graphical abstract: Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(iii) complexes

Supplementary files

Article information

Article type
Communication
Submitted
16 Dec 2016
Accepted
18 Jan 2017
First published
18 Jan 2017

Chem. Commun., 2017,53, 2052-2055

Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes

J. Liu, C. Jin, B. Yuan, X. Liu, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2017, 53, 2052 DOI: 10.1039/C6CC10015E

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