Issue 16, 2017

Natural product analogues: towards a blueprint for analogue-focused synthesis

Abstract

For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

Graphical abstract: Natural product analogues: towards a blueprint for analogue-focused synthesis

Article information

Article type
Review Article
Submitted
25 Nov 2016
First published
04 Jul 2017

Chem. Soc. Rev., 2017,46, 5059-5109

Natural product analogues: towards a blueprint for analogue-focused synthesis

M. W. P. Bebbington, Chem. Soc. Rev., 2017, 46, 5059 DOI: 10.1039/C6CS00842A

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