Issue 8, 2017

Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis

Abstract

1,2-Carbon atom rearrangement has been broadly applied as a guiding strategy in complex molecule assembly. As it entails the carbon–carbon or carbon–heteroatom bond migration between two vicinal atoms, this type of reaction is capable of generating structural complexity through a molecular skeletal reorganization. This review will focus on recent employment of this strategy in the total synthesis of natural products, highlighting the exceptional utility of such synthetic methodologies in the construction of intricate carbocycles, heterocycles or structurally complex motifs from synthetically more accessible precursors.

Graphical abstract: Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis

Article information

Article type
Review Article
Submitted
26 Dec 2016
First published
28 Mar 2017

Chem. Soc. Rev., 2017,46, 2272-2305

Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis

X. Zhang, Y. Tu, F. Zhang, Z. Chen and S. Wang, Chem. Soc. Rev., 2017, 46, 2272 DOI: 10.1039/C6CS00935B

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