Issue 21, 2016
From the journal:

Dalton Transactions

Tuning the reactivity of Sp1 zinc fingers with platinum complexes†

Zhifeng Du,a   Raphael E. F. de Paiva,ab   Yun Qua  and  Nicholas Farrell*a  

* Corresponding authors

a Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA
E-mail: npfarrell@vcu.edu

b Institute of Chemistry, University of Campinas, Campinas, SP, Brazil

Abstract

cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}2-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.

Graphical abstract: Tuning the reactivity of Sp1 zinc fingers with platinum complexes

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Article information

DOI
https://doi.org/10.1039/C6DT01128D
Article type
Communication
Submitted
22 Mar 2016
Accepted
06 May 2016
First published
06 May 2016

Dalton Trans., 2016,45, 8712-8716

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Tuning the reactivity of Sp1 zinc fingers with platinum complexes

Z. Du, R. E. F. de Paiva, Y. Qu and N. Farrell, Dalton Trans., 2016, 45, 8712 DOI: 10.1039/C6DT01128D

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