Issue 32, 2016
From the journal:

Dalton Transactions

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?†

Clémence Cheignon,abc   Fabrice Collin,abc   Peter Faller‡*ab  and  Christelle Hureau*ab  

* Corresponding authors

a LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205 route de Narbonne, 31062 Toulouse Cedex 09, France
E-mail: christelle.hureau@lcc-toulouse.fr

b Université de Toulouse; UPS, INPT, 31077 Toulouse, France

c UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France

Abstract

Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.

Graphical abstract: Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

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Article information

DOI
https://doi.org/10.1039/C6DT01979J
Article type
Communication
Submitted
17 May 2016
Accepted
23 May 2016
First published
24 May 2016
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2016,45, 12627-12631

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Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

C. Cheignon, F. Collin, P. Faller and C. Hureau, Dalton Trans., 2016, 45, 12627 DOI: 10.1039/C6DT01979J

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