Issue 17, 2016

Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

Abstract

A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield.

Graphical abstract: Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2016
Accepted
14 Jul 2016
First published
14 Jul 2016
This article is Open Access
Creative Commons BY license

Green Chem., 2016,18, 4623-4627

Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

M. R. Chapman, M. H. T. Kwan, G. E. King, B. A. Kyffin, A. J. Blacker, C. E. Willans and B. N. Nguyen, Green Chem., 2016, 18, 4623 DOI: 10.1039/C6GC01601D

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