We describe herein the first, straightforward, green, and metal-free tandem continuous flow pseudo-four component reaction to form 3-aminohexahydrocoumarins using choline chloride–urea as a natural deep eutectic solvent. This technology exhibited superior yields relative to the batch reactions.
P. Zamani and A. R. Khosropour, Green Chem., 2016, 18, 6450 DOI: 10.1039/C6GC02642G
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