Issue 24, 2016

A highly efficient metal-free approach to meta- and multiple-substituted phenols via a simple oxidation of cyclohexenones

Abstract

A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.

Graphical abstract: A highly efficient metal-free approach to meta- and multiple-substituted phenols via a simple oxidation of cyclohexenones

Supplementary files

Article information

Article type
Communication
Submitted
25 Sep 2016
Accepted
30 Oct 2016
First published
31 Oct 2016

Green Chem., 2016,18, 6462-6467

A highly efficient metal-free approach to meta- and multiple-substituted phenols via a simple oxidation of cyclohexenones

Y. Liang, S. Song, L. Ai, X. Li and N. Jiao, Green Chem., 2016, 18, 6462 DOI: 10.1039/C6GC02674E

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