Issue 1, 2017

A deeper shade of green: inspiring sustainable drug manufacturing

Abstract

Green and sustainable drug manufacturing go hand in hand with forward-looking visions seeking to balance the long-term sustainability of business, society, and the environment. However, a lack of harmonization among available metrics has inhibited opportunities for green chemistry in industry. Moreover, inconsistent starting points for analysis and neglected complexities for diverse manufacturing processes have made developing objective goals a challenge. Herein we put forward a practical strategy to overcome these barriers using data from in-depth analysis of 46 drug manufacturing processes from nine large pharmaceutical firms, and propose the Green Aspiration Level as metric of choice to enable the critically needed consistency in smart green manufacturing goals. In addition, we quantify the importance of green chemistry in the often overlooked, yet enormously impactful, outsourced portion of the supply chain, and introduce the Green Scorecard as a value added sustainability communication tool.

Graphical abstract: A deeper shade of green: inspiring sustainable drug manufacturing

Supplementary files

Article information

Article type
Paper
Submitted
19 Oct 2016
Accepted
15 Nov 2016
First published
22 Nov 2016

Green Chem., 2017,19, 281-285

A deeper shade of green: inspiring sustainable drug manufacturing

F. Roschangar, J. Colberg, P. J. Dunn, F. Gallou, J. D. Hayler, S. G. Koenig, M. E. Kopach, D. K. Leahy, I. Mergelsberg, J. L. Tucker, R. A. Sheldon and C. H. Senanayake, Green Chem., 2017, 19, 281 DOI: 10.1039/C6GC02901A

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