Issue 1, 2017

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Abstract

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.

Graphical abstract: Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Supplementary files

Article information

Article type
Research Article
Submitted
30 Aug 2016
Accepted
14 Nov 2016
First published
15 Nov 2016

Med. Chem. Commun., 2017,8, 198-201

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

W. Niu, P. Wu, F. Chen, J. Wang, X. Shang and C. Xu, Med. Chem. Commun., 2017, 8, 198 DOI: 10.1039/C6MD00493H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements