An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

Abstract

An efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed. The reaction proceeded smoothly in the presence of In(OTf)₃ and afforded a broad scope of isoindolinones with moderate to good yields. Moreover, the reaction could be run on a gram-scale with comparable yield.