Issue 16, 2016

Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H2O2 and glucose

Abstract

Blood glucose detecting has aroused considerable attention because diabetes mellitus has become a worldwide publish health problem. Herein, we construct an exceptionally simple upconverting hybrid nanocomposite, composed of DNA-templated Ag nanoparticles (DNA-AgNPs) and NaYF4:Yb/Tm@NaYF4 core–shell upconversion nanoparticles (UCNPs), for the sensing of H2O2 and glucose. In this design, UCNPs with bared surface act as the donor, and DNA-AgNPs serve as efficient quenchers. DNA-AgNPs can be directly assembled on the bared surface of UCNPs, which further decreases the distance of donor-to-acceptor. The formation of DNA-AgNPs/UCNP nanocomposite results in luminescence quenching of UCNP by DNA-AgNPs through luminescence resonance energy transfer (LRET). Upon H2O2 addition, AgNPs can be etched and transformed into Ag+, leading to inhibition of the LRET process and causing the recovery of upconversion luminescence. Based on the conversion of glucose into H2O2 by glucose oxidase, the DNA-AgNPs/UCNP nanocomposite can also be exploited for glucose sensing. Moreover, due to the non-autofluorescence offered by UCNPs, the approach developed can be applied to monitor glucose levels in human serum samples with satisfactory results.

Graphical abstract: Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H2O2 and glucose

Supplementary files

Article information

Article type
Paper
Submitted
19 Jan 2016
Accepted
27 Mar 2016
First published
29 Mar 2016

Nanoscale, 2016,8, 8939-8946

Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H2O2 and glucose

S. Wu, X. Kong, Y. Cen, J. Yuan, R. Yu and X. Chu, Nanoscale, 2016, 8, 8939 DOI: 10.1039/C6NR00470A

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