A photothermally responsive nanoprobe for bioimaging based on Edman degradation

Yi Liu; Zhantong Wang; Huimin Zhang; Lixin Lang; Ying Ma; Qianjun He; Nan Lu; Peng Huang; Yijing Liu; Jibin Song; Zhibo Liu; Shi Gao; Qingjie Ma; Dale O. Kiesewetter; Xiaoyuan Chen

doi:10.1039/C6NR01400C

A photothermally responsive nanoprobe for bioimaging based on Edman degradation†

Yi Liu,^ab Zhantong Wang,^b Huimin Zhang,^b Lixin Lang,^b Ying Ma,^b Qianjun He,^b Nan Lu,^b Peng Huang,^b Yijing Liu,^b Jibin Song,^b Zhibo Liu,^b Shi Gao,^a Qingjie Ma,*^a Dale O. Kiesewetter*^b and Xiaoyuan Chen*^b

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* Corresponding authors

^a China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
E-mail: maqj@jlu.edu.cn

^b Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA
E-mail: dkiesewetter@mail.nih.gov, shawn.chen@nih.gov

Abstract

A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of α_νβ₃ over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based nanoprobe provides a novel strategy to design activatable probes for biomedical imaging and drug/gene delivery.

Nanoscale

A photothermally responsive nanoprobe for bioimaging based on Edman degradation†

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A photothermally responsive nanoprobe for bioimaging based on Edman degradation

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