Issue 27, 2016

Surface engineering of bismuth nanocrystals to counter dissolution

Abstract

Rapid dissolution of Bi Nanocrystals (NCs) in lysosomal conditions results in poor biocompatibility. We report that an in situ surface coating of Bi nanocrystals with Ganex® V216, a cosmetic dispersant, limits its dissolution under physiological conditions. These Bi Ganex (BiG) NCs are readily encapsulated in FDA approved polymer poly(DL-lactic-co-glycolic acid) (PLGA) by an oil-in-water emulsion technique and also undergo facile SiO2 coating. BiG NCs in BiG@PLGA and BiG@SiO2 nanoparticles dissolve slowly under physiological conditions and exhibit excellent biocompatibility, as opposed to uncoated Bi NCs. Finally, these Bi nanoconstructs are shown to be strong CT CAs, even at relatively low Bi concentrations.

Graphical abstract: Surface engineering of bismuth nanocrystals to counter dissolution

Supplementary files

Article information

Article type
Communication
Submitted
15 Mar 2016
Accepted
19 Jun 2016
First published
21 Jun 2016

Nanoscale, 2016,8, 13217-13222

Surface engineering of bismuth nanocrystals to counter dissolution

S. Chakravarty, J. Unold, D. D. Shuboni-Mulligan, B. Blanco-Fernandez and E. M. Shapiro, Nanoscale, 2016, 8, 13217 DOI: 10.1039/C6NR02171A

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