Issue 25, 2016

Smart surface-enhanced Raman scattering traceable drug delivery systems

Abstract

A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.

Graphical abstract: Smart surface-enhanced Raman scattering traceable drug delivery systems

Supplementary files

Article information

Article type
Paper
Submitted
13 May 2016
Accepted
27 May 2016
First published
30 May 2016
This article is Open Access
Creative Commons BY license

Nanoscale, 2016,8, 12803-12811

Author version available

Smart surface-enhanced Raman scattering traceable drug delivery systems

L. Liu, Y. Tang, S. Dai, F. Kleitz and S. Z. Qiao, Nanoscale, 2016, 8, 12803 DOI: 10.1039/C6NR03869G

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