Issue 22, 2016

Imidazolylpyridine-In(OTf)3 catalyzed enantioselective allylation of ketimines derived from isatins

Abstract

An enantioselective In(OTf)3-catalyzed allylation of ketimines derived from isatins in the presence of an imidazolylpyridine ligand is described. The reaction proceeded smoothly under mild conditions and resulted in 3-allyl 3-aminooxindoles with good yields and moderate to excellent enantioselectivities (up to 97% ee).

Graphical abstract: Imidazolylpyridine-In(OTf)3 catalyzed enantioselective allylation of ketimines derived from isatins

Supplementary files

Article information

Article type
Communication
Submitted
13 Mar 2016
Accepted
06 May 2016
First published
10 May 2016

Org. Biomol. Chem., 2016,14, 5019-5022

Imidazolylpyridine-In(OTf)3 catalyzed enantioselective allylation of ketimines derived from isatins

T. Chen and C. Cai, Org. Biomol. Chem., 2016, 14, 5019 DOI: 10.1039/C6OB00551A

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