Issue 26, 2016

Metal free TBHP-promoted intramolecular carbonylation of arenes via radical cross-dehydrogenative coupling: synthesis of indenoquinolinones, 4-azafluorenones and fluorenones

Abstract

A metal-free, TBHP-promoted economical route is developed via the sp2 C–H bond functionalization strategy for the synthesis of indenoquinolinones, 4-azafluorenones and fluorenones. Reactions provided excellent yield of the products under mild conditions. We have successfully synthesized 11H-indeno[1,2-b]quinolin-11-one, an antibacterial agent, in excellent yields.

Graphical abstract: Metal free TBHP-promoted intramolecular carbonylation of arenes via radical cross-dehydrogenative coupling: synthesis of indenoquinolinones, 4-azafluorenones and fluorenones

Supplementary files

Article information

Article type
Paper
Submitted
07 May 2016
Accepted
27 May 2016
First published
07 Jun 2016

Org. Biomol. Chem., 2016,14, 6328-6336

Metal free TBHP-promoted intramolecular carbonylation of arenes via radical cross-dehydrogenative coupling: synthesis of indenoquinolinones, 4-azafluorenones and fluorenones

K. Mishra, A. K. Pandey, J. B. Singh and R. M. Singh, Org. Biomol. Chem., 2016, 14, 6328 DOI: 10.1039/C6OB00998K

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