Issue 33, 2016

Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands

Abstract

It was found that the tridentate O,N,O-type Schiff base ligand bearing suitable substituents was a highly effective promoter in the catalytic asymmetric bromochlorination reaction, in which the corresponding aromatic bromochloroalcohols with vicinal halogen-bearing stereocenters were formed with perfect regioselectivity, with moderate to excellent enantioselectivities (up to 93% ee), and with good yields and chemoselectivities.

Graphical abstract: Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2016
Accepted
28 Jul 2016
First published
28 Jul 2016

Org. Biomol. Chem., 2016,14, 7927-7932

Catalytic asymmetric bromochlorination of aromatic allylic alcohols promoted by multifunctional Schiff base ligands

W. Huang, L. Chen, Z. Zheng, K. Yang, Z. Xu, Y. Cui and L. Xu, Org. Biomol. Chem., 2016, 14, 7927 DOI: 10.1039/C6OB01306F

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