Issue 40, 2016

Rapid assembly of spirocycles with phenol-derived biaryls with alkynes using an oxidative C–H activation/dearomatization strategy

Abstract

The development of new methods for the rapid assembly of spirocyclic frameworks with high molecular complexity is always of great importance for organic syntheses. In this perspective, we endeavour to cover the recent achievements from our group in the construction of synthetically valuable spirocyclohexadienones from easily accessible phenol-derived biaryls using a transition-metal-catalyzed C–H activation/dearomatization strategy. The key feature of these cooperative reactions is the simultaneous C–H bond activation and aromaticity disruption, leading to the formation of various spirocyclic molecules that are difficult or inaccessible using conventional approaches.

Graphical abstract: Rapid assembly of spirocycles with phenol-derived biaryls with alkynes using an oxidative C–H activation/dearomatization strategy

Article information

Article type
Perspective
Submitted
02 Aug 2016
Accepted
30 Aug 2016
First published
30 Aug 2016

Org. Biomol. Chem., 2016,14, 9451-9455

Rapid assembly of spirocycles with phenol-derived biaryls with alkynes using an oxidative C–H activation/dearomatization strategy

H. Wang and X. Luan, Org. Biomol. Chem., 2016, 14, 9451 DOI: 10.1039/C6OB01660J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements