Issue 26, 2016

An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy

Abstract

A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized via reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of a cyanine NIR dye. Reactions were traced by means of 1H-NMR, GPC and FT-IR. The NIR amphiphilic copolymer with polycaprolactone and polycarborane as hydrophobic segments and poly(ethylene glycol)methyl ether methacrylate as the hydrophilic segment could self-assemble into micelles in aqueous solution, and was characterized by means of DLS and TEM. In the copolymer, carborane works as a boron neutron capture therapy (BNCT) agent while the aminocyanine (Cy) dye works as a NIR bioimaging agent, and the nanoparticles of the copolymers are a potential theranostic BNCT system for cancer therapy, which was supported by MTT experiments and in vitro fluorescence microscopy studies.

Graphical abstract: An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy

Supplementary files

Article information

Article type
Paper
Submitted
07 May 2016
Accepted
31 May 2016
First published
07 Jun 2016

Polym. Chem., 2016,7, 4411-4418

An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy

Z. Ruan, L. Liu, L. Fu, T. Xing and L. Yan, Polym. Chem., 2016, 7, 4411 DOI: 10.1039/C6PY00799F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements