Issue 5, 2016

A copper-catalyzed cascade reaction of o-bromoarylisothiocyanates with isocyanides leading to benzo[d]imidazo[5,1-b]thiazoles under ligand-free conditions

Abstract

A convenient and efficient copper-catalyzed domino method has been initially developed for the synthesis of benzo[d]imidazo[5,1-b]thiazole derivatives via the reactions of readily available substituted o-bromoarylisothiocyanates with isocyanides under ligand-free conditions. This chemistry involves intermolecular [3 + 2] cycloaddition and intramolecular Ullmann-type C–S bond formation.

Graphical abstract: A copper-catalyzed cascade reaction of o-bromoarylisothiocyanates with isocyanides leading to benzo[d]imidazo[5,1-b]thiazoles under ligand-free conditions

Supplementary files

Article information

Article type
Research Article
Submitted
19 Jan 2016
Accepted
26 Feb 2016
First published
29 Feb 2016

Org. Chem. Front., 2016,3, 556-560

A copper-catalyzed cascade reaction of o-bromoarylisothiocyanates with isocyanides leading to benzo[d]imidazo[5,1-b]thiazoles under ligand-free conditions

K. Yan, D. Yang, W. Wei, P. Sun, Y. Lu and H. Wang, Org. Chem. Front., 2016, 3, 556 DOI: 10.1039/C6QO00030D

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