Issue 2, 2017
From the journal:

Organic Chemistry Frontiers

Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature†

Mei-jie Bu,a   Guo-ping Lua  and  Chun Cai*ab  

* Corresponding authors

a Chemical Engineering College, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing, Jiangsu 210094, P. R. China
E-mail: c.cai@mail.njust.edu.cn

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 20032, P. R. China

Abstract

A transition-metal-free direct trifluoromethylthiolation of indole derivatives under mild conditions has been developed. Commercially available sodium trifluoromethanesulfinate (CF3SO2Na) acts as the trifluoromethylthiolating reagent, which is cheap, stable and easy to handle. The substrate scope of this protocol could also be expanded to pyrroles and enamines.

Graphical abstract: Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature

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Article information

DOI
https://doi.org/10.1039/C6QO00622A
Article type
Research Article
Submitted
11 Oct 2016
Accepted
25 Nov 2016
First published
29 Nov 2016

Org. Chem. Front., 2017,4, 266-270

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Transition-metal-free electrophilic trifluoromethylthiolation with sodium trifluoromethanesulfinate at room temperature

M. Bu, G. Lu and C. Cai, Org. Chem. Front., 2017, 4, 266 DOI: 10.1039/C6QO00622A

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