Issue 3, 2017
From the journal:

Organic Chemistry Frontiers

Copper nitrate-mediated chemo- and regioselective annulation from two different alkynes: a direct route to isoxazoles†

Yingying Li,‡a   Mingchun Gao,‡a   Bingxin Liua  and  Bin Xu ORCID logo *abc  

* Corresponding authors

a Department of Chemistry, School of Materials Science and Engineering, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China
E-mail: xubin@shu.edu.cn

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

c Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China

Abstract

An efficient copper nitrate-mediated annulation reaction was developed for the direct synthesis of pharmacologically interesting polysubstituted isoxazoles in good to excellent yields from two different alkynes with high chemo- and regioselectivities by syringe pump infusion.

Graphical abstract: Copper nitrate-mediated chemo- and regioselective annulation from two different alkynes: a direct route to isoxazoles

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Article information

DOI
https://doi.org/10.1039/C6QO00704J
Article type
Research Article
Submitted
10 Nov 2016
Accepted
19 Dec 2016
First published
20 Dec 2016

Org. Chem. Front., 2017,4, 445-449

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Copper nitrate-mediated chemo- and regioselective annulation from two different alkynes: a direct route to isoxazoles

Y. Li, M. Gao, B. Liu and B. Xu, Org. Chem. Front., 2017, 4, 445 DOI: 10.1039/C6QO00704J

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