Issue 30, 2016
From the journal:

RSC Advances

Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones†

Gao-Fei Pan,a   Li Su,a   Yan-Lei Zhang,a   Shi-Huan Guoa  and  Yong-Qiang Wang*a  

* Corresponding authors

a Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, P.R. China
E-mail: wangyq@nwu.edu.cn

Abstract

A highly efficient organocatalytic one-pot enantioselective synthesis of (R)-2-aryl-2,3-dihydro-4-quinolones from o-aminoacetophenones and aryl aldehydes has been developed. The approach is characterized by being metal free, solvent free and protecting group free. A variety of 2-aryl-2,3-dihydro-4-quinolones could be obtained in good yields up to 99% ee.

Graphical abstract: Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones

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Article information

DOI
https://doi.org/10.1039/C6RA01247G
Article type
Communication
Submitted
15 Jan 2016
Accepted
29 Feb 2016
First published
02 Mar 2016

RSC Adv., 2016,6, 25375-25378

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Organocatalytic one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones

G. Pan, L. Su, Y. Zhang, S. Guo and Y. Wang, RSC Adv., 2016, 6, 25375 DOI: 10.1039/C6RA01247G

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