Rhodol-based fluorescent probe for Au3+ detection and its application in bioimaging

Kanokorn Wechakorn; Samran Prabpai; Kanoknetr Suksen; Pawinee Piyachaturawat; Palangpon Kongsaeree

doi:10.1039/C6RA02342H

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Rhodol-based fluorescent probe for Au³⁺ detection and its application in bioimaging†

Kanokorn Wechakorn,^ab Samran Prabpai,^ab Kanoknetr Suksen,^c Pawinee Piyachaturawat^c and Palangpon Kongsaeree*^ab

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* Corresponding authors

^a Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
E-mail: palangpon.kon@mahidol.ac.th
Fax: +66-2-354-7151
Tel: +66-2-201-5190

^b Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

^c Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Abstract

A turn-on fluorescent probe of propargyl–rhodol conjugate responds selectively to Au³⁺. In the presence of Au³⁺, the chemodosimeter undergoes a remarkable change in its absorption spectrum with a 370-fold fluorescence enhancement. This reaction-based Au³⁺ chemodosimeter is highly sensitive with a detection limit of 7 ppb through an irreversible mechanism. Bioimaging of HeLa cells with this chemical probe has been successfully demonstrated.

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Article information

DOI: https://doi.org/10.1039/C6RA02342H
Article type: Communication
Submitted: 26 Jan 2016
Accepted: 26 Feb 2016
First published: 29 Feb 2016

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RSC Adv., 2016,6, 24752-24755

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Rhodol-based fluorescent probe for Au³⁺ detection and its application in bioimaging

K. Wechakorn, S. Prabpai, K. Suksen, P. Piyachaturawat and P. Kongsaeree, RSC Adv., 2016, 6, 24752 DOI: 10.1039/C6RA02342H

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