Issue 37, 2016, Issue in Progress

Radar-like MoS2 nanoparticles as a highly efficient 808 nm laser-induced photothermal agent for cancer therapy

Abstract

MoS2, a typical transition-metal dichalcogenide, has attracted increasing attention in the field of biomedicine due to its preeminent properties. In this paper, MoS2 nanoparticles with radar-like shapes were demonstrated as 808 nm laser-induced photothermal agents with outstanding photothermal performance. According to our calculations, the radar-like morphology endowed the MoS2 nanoparticles with higher photothermal conversion efficiency (53.3%) compared to other morphologies including nanoflowers, microspheres and irregular nanoparticles. Cytotoxicity assay indicated that the radar-like nanoparticles were biocompatible. Results of in vitro photothermal therapy and apoptosis assay indicated that tumor cells treated with MoS2 radar-like nanoparticles can be seriously damaged. Photothermal therapy on tumor-bearing mice was carried out to further verify the anti-cancer properties of the MoS2 radar-like nanoparticles. All the aforementioned results suggested that the MoS2 radar-like nanoparticles exhibit enormous potential for cancer photothermal therapy.

Graphical abstract: Radar-like MoS2 nanoparticles as a highly efficient 808 nm laser-induced photothermal agent for cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
03 Feb 2016
Accepted
10 Mar 2016
First published
11 Mar 2016

RSC Adv., 2016,6, 31031-31036

Radar-like MoS2 nanoparticles as a highly efficient 808 nm laser-induced photothermal agent for cancer therapy

Z. Huang, Y. Qi, D. Yu and J. Zhan, RSC Adv., 2016, 6, 31031 DOI: 10.1039/C6RA03226E

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