Issue 28, 2016
From the journal:

RSC Advances

An upconversion nanoparticle/Ru(ii) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent†

Yumeng Chen,ab   Guoyu Jiang,*a   Qianxiong Zhou,a   Yangyang Zhang,ab   Ke Li,ab   Yue Zheng,ab   Baowen Zhanga  and  Xuesong Wang*a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, jiangguoyu@mail.ipc.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

Photoactivated anticancer chemotherapy distinguishes itself by its high selectivity by virtue of the spatiotemporal control of irradiation. However, short photoactivation wavelengths limit its application. Herein, an amphiphilic Ru(II) complex, cis-[Ru(bpy)2(C18H37CN)2]2+ (bpy = 2,2′-bipyridine), was embedded along with a poly(ethylene glycol, PEG)-modified lipid onto the surfaces of oleate-capped lanthanide-doped upconversion nanoparticles (UCNPs). The resultant core–shell hybrid system is water-dispersible, stable in the dark, and releases a DNA covalent-binding agent of [Ru(bpy)2(H2O)2]2+ upon 980 nm laser irradiation, providing guidelines for developing near-infrared (NIR) light triggered chemotherapeutics.

Graphical abstract: An upconversion nanoparticle/Ru(ii) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent

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Article information

DOI
https://doi.org/10.1039/C6RA03396B
Article type
Paper
Submitted
05 Feb 2016
Accepted
23 Feb 2016
First published
25 Feb 2016

RSC Adv., 2016,6, 23804-23808

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An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent

Y. Chen, G. Jiang, Q. Zhou, Y. Zhang, K. Li, Y. Zheng, B. Zhang and X. Wang, RSC Adv., 2016, 6, 23804 DOI: 10.1039/C6RA03396B

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