Issue 54, 2016, Issue in Progress
From the journal:

RSC Advances

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent†

Tae-Hyun Kim,‡a   Jun Young Lee,‡bc   Min-Kyu Kim,a   Jeong Hoon Park*b  and  Jae-Min Oh*a  

* Corresponding authors

a Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwondo, Korea
E-mail: jaemin.oh@yonsei.ac.kr

b Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup, Korea
E-mail: parkjh@kaeri.re.kr

c Department of Advanced Material Chemistry, Dongguk University-Gyeongju, Gyeongju, Korea

Abstract

Radioisotope Co-57 was stably incorporated into a framework of layered double hydroxide nanoparticles through isomorphous substitution. An in vitro cellular uptake test resulted in ∼45 ID% high radioactivity delivering efficiency. In vivo biodistribution demonstrated time-dependent tumor accumulation of Co-57 by LDH showing high tumor-to-organ ratios.

Graphical abstract: Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

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Article information

DOI
https://doi.org/10.1039/C6RA06256C
Article type
Communication
Submitted
09 Mar 2016
Accepted
10 May 2016
First published
11 May 2016

RSC Adv., 2016,6, 48415-48419

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Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

T. Kim, J. Y. Lee, M. Kim, J. H. Park and J. Oh, RSC Adv., 2016, 6, 48415 DOI: 10.1039/C6RA06256C

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