Issue 52, 2016, Issue in Progress

Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

Abstract

The natural tripeptide glutathione has become a popular choice for passivating the surface of gold nanoparticles (NPs) intended for in vivo applications. Here we investigate a zwitterionic derivative of glutathione – glutathione monoethyl ester – as a new capping ligand for ultrasmall NPs. The new zwitterionic particles (AuGSH(zwt)) were colloidally stable in biological media and resistant against binding from serum proteins. AuGSH(zwt), but not glutathione-coated particles, could be successfully functionalized with strep-tag II for binding specifically to target streptactin in the presence of serum proteins. Taken together, these results place AuGSH(zwt) as a promising choice for attaining simultaneous in vivo renal clearance and targeted delivery via incorporation of functional peptides.

Graphical abstract: Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
25 Mar 2016
Accepted
04 May 2016
First published
06 May 2016

RSC Adv., 2016,6, 46350-46355

Author version available

Zwitterionic glutathione monoethyl ester as a new capping ligand for ultrasmall gold nanoparticles

L. L. Knittel, P. Schuck, C. J. Ackerson and A. A. Sousa, RSC Adv., 2016, 6, 46350 DOI: 10.1039/C6RA07777C

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