Issue 52, 2016, Issue in Progress

Antimicrobial and osteogenic properties of iron-doped titanium

Abstract

Iron (Fe) was doped into the surface of pure titanium by iron plasma immersion ion implantation (Fe PIII), so that a nano-thick surface layer, composed of abundant reactive sites and capable of producing reactive oxygen species (ROS), was produced on the material. In vitro results demonstrated that the Fe PIII treated titanium was able to inhibit bacterial adhesion (E. coli and P. aeruginosa), but facilitate the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 and/or rBMSCs. The antibacterial efficacy of Fe PIII groups is likely determined by both the intrinsic potential of the materials in ROS generation and the availability of electrons supplied by respiration electron transport chains (ETC) in bacterial cells, which is important to the cytocompatibility of the materials. This study revealed that doping of iron can modify the electrochemical behavior of titanium and regulate its potential on production of ROS, which controls the selective nature of biomaterials in toxicity.

Graphical abstract: Antimicrobial and osteogenic properties of iron-doped titanium

Supplementary files

Article information

Article type
Paper
Submitted
01 Apr 2016
Accepted
03 May 2016
First published
04 May 2016

RSC Adv., 2016,6, 46495-46507

Antimicrobial and osteogenic properties of iron-doped titanium

Y. Tian, H. Cao, Y. Qiao and X. Liu, RSC Adv., 2016, 6, 46495 DOI: 10.1039/C6RA08359E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements