Issue 70, 2016, Issue in Progress
From the journal:

RSC Advances

Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models†

Nathalie M. Pinkerton,*a   Céline Frongia,a   Valérie Lobjois,a   Brian K. Wilson,b   Matthew J. Bruzek,c   Robert K. Prud'homme,b   John Anthony,c   Frédéric Bolzed  and  Stefan Chassaing*a  

* Corresponding authors

a ITAV, Université de Toulouse, CNRS, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France
E-mail: nathalie.pinkerton@itav.fr, stefan.chassaing@itav.fr

b Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA

c Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA

d Laboratoire de Conception et Application des Molécules Bioactives, UMR 7199, Equipe de Chimie et Neurologie Moléculaire, Faculté de Pharmacie, Université de Strasbourg, 67401 IllKirch-Graffenstaden, France

Abstract

Biocompatible and biostable EtTP-5-loaded organic core–shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

Graphical abstract: Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

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Article information

DOI
https://doi.org/10.1039/C6RA09954H
Article type
Communication
Submitted
17 Apr 2016
Accepted
05 Jul 2016
First published
06 Jul 2016

RSC Adv., 2016,6, 65770-65774

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Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models

N. M. Pinkerton, C. Frongia, V. Lobjois, B. K. Wilson, M. J. Bruzek, R. K. Prud'homme, J. Anthony, F. Bolze and S. Chassaing, RSC Adv., 2016, 6, 65770 DOI: 10.1039/C6RA09954H

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