A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3 via a radical mechanism process is described. This methodology provides an easy access to a variety of useful 5-substituted isoxazoles from simple and readily available propargylic ketones and TMSN3 in good to excellent yields. A plausible reaction mechanism for this process is proposed.
Y. He, Y. Xie, Y. Wang, X. Bin, D. Hu, H. Wang and Y. Pan, RSC Adv., 2016, 6, 58988 DOI: 10.1039/C6RA11099A
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