FeF3-catalyzed MCR in PEG-400: ultrasound assisted synthesis of N-substituted 2-aminopyridines

Abstract

FeF₃ catalyzed four component reaction under ultrasound irradiation was explored for the first time to prepare N-substituted 2-aminopyridines in good yields. The methodology involved the use of readily available starting materials and PEG-400 under mild reaction conditions in the presence of air. The one-pot methodology afforded a range of compounds of pharmacological interest indicating its potential in generating a diversity based library of small molecules useful for medicinal chemistry and drug discovery.