Issue 81, 2016

Enhanced magnetic properties and MRI performance of bi-magnetic core–shell nanoparticles

Abstract

Two sets of bi-magnetic Zn0.5Mn0.5Fe2O4@Fe3O4 core–shell nanoparticles were prepared by a seed-mediated modified co-precipitation method. While the first set was obtained by fast addition of the alkaline solution to grow Fe3O4 shells over the ferrite seeds, a slow drop-wise addition of stoichiometric Fe2+/Fe3+ ion solution to the alkaline ferrite seeds solution was adopted to synthesize the second set. Samples were characterized by electron microscopy (STEM, TEM, UHRTEM) and magnetometry measurements. Viability MTT assay of the nanoparticles on L929 murine fibroblasts were performed, indicating that they are biocompatible. The coating of the Zn0.5Mn0.5FeO4 nanoparticle by a magnetite or maghemite shell minimizes the effect of the magnetic dead layer at the core surface, improving the magnetic properties and offering thus outstanding values for biological application. Relaxometry values r2 higher than 300 mM−1 s−1 at H 1.5 T, and cell viability at concentrations as high as 0.5 mg mL−1 means these bi-magnetic nanoparticles have a vast potential as MRI contrast agents.

Graphical abstract: Enhanced magnetic properties and MRI performance of bi-magnetic core–shell nanoparticles

Article information

Article type
Paper
Submitted
01 Jun 2016
Accepted
02 Aug 2016
First published
10 Aug 2016

RSC Adv., 2016,6, 77558-77568

Enhanced magnetic properties and MRI performance of bi-magnetic core–shell nanoparticles

F. A. Cardona, E. S. Urquiza, P. D. L. Presa, S. H. Tobón, U. Pal, P. H. Fraijo, M. J. Yacaman, J. D. Lozada Ramírez, R. Ivkov, A. Angulo-Molina and M. Á. Méndez-Rojas, RSC Adv., 2016, 6, 77558 DOI: 10.1039/C6RA14265F

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