Issue 72, 2016
From the journal:

RSC Advances

Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles†

Xiaobing Yang,a   Yang Wang,a   Fangzhong Hu,*a   Xiaoli Kan,a   Chiming Yang,a   Jiahui Liu,a   Pei Liua  and  Qichun Zhang*bc  

* Corresponding authors

a State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: fzhu@nankai.edu.cn

b School of Materials Science Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 637371, Singapore
E-mail: qczhang@ntu.edu.sg

c Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Abstract

An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic β-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic β-enaminones in moderate to good yields.

Graphical abstract: Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

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Article information

DOI
https://doi.org/10.1039/C6RA14897B
Article type
Paper
Submitted
08 Jun 2016
Accepted
14 Jul 2016
First published
14 Jul 2016

RSC Adv., 2016,6, 68454-68459

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Base-promoted intramolecular cyclization of N-alkyl, N-propargylic β-enaminones for the synthesis of polysubstituted pyrroles

X. Yang, Y. Wang, F. Hu, X. Kan, C. Yang, J. Liu, P. Liu and Q. Zhang, RSC Adv., 2016, 6, 68454 DOI: 10.1039/C6RA14897B

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