Issue 82, 2016, Issue in Progress

Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

Abstract

A novel and convenient copper-catalyzed oxidative amidation for the synthesis of α-ketoamides has been successfully developed, which uses easily available O-benzoyl hydroxylamines as aminating reagent and oxidant. The reaction proceeds smoothly at room temperature and is compatible with a range of substrates to give the desired products in moderate to good yields.

Graphical abstract: Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2016
Accepted
10 Aug 2016
First published
11 Aug 2016

RSC Adv., 2016,6, 78307-78310

Room temperature copper-catalyzed oxidative amidation of terminal alkynes for the synthesis of α-ketoamides using O-benzoyl hydroxylamines as aminating reagent and oxidant

G. Shen, L. zhao, Y. Wang and T. Zhang, RSC Adv., 2016, 6, 78307 DOI: 10.1039/C6RA15219H

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