Issue 78, 2016
From the journal:

RSC Advances

Modulating the DNA strand-displacement kinetics with the one-sided remote toehold design for differentiation of single-base mismatched DNA†

Chenxi Li,a   Yixin Li,a   Yang Chen,a   Ruoyun Lin,a   Tian Li,a   Feng Liua  and  Na Li*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
E-mail: lina@pku.edu.cn

Abstract

A one-sided remote toehold design was proposed to provide the fine control over strand-displacement reaction kinetics with simplicity and versatility. The significantly improved single-base mismatch differentiating ability of reactions was achieved for strand-displacement reaction systems with the rate-saturated toehold length.

Graphical abstract: Modulating the DNA strand-displacement kinetics with the one-sided remote toehold design for differentiation of single-base mismatched DNA

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Article information

DOI
https://doi.org/10.1039/C6RA17006D
Article type
Communication
Submitted
02 Jul 2016
Accepted
02 Aug 2016
First published
02 Aug 2016

RSC Adv., 2016,6, 74913-74916

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Modulating the DNA strand-displacement kinetics with the one-sided remote toehold design for differentiation of single-base mismatched DNA

C. Li, Y. Li, Y. Chen, R. Lin, T. Li, F. Liu and N. Li, RSC Adv., 2016, 6, 74913 DOI: 10.1039/C6RA17006D

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