Halogenations of substituted 2-alkylquinoline with iodine and halide exchange with AgF2

Abstract

Halogenations of substituted 2-alkylquinoline with iodine and halide exchange with AgF₂ have been developed. These processes provide facile strategies to construct C–I/F bonds, and expand the methods of fluorination of 2-alkylquinolines. These transformations exhibit good tolerance of functional groups and generate the desired products in moderate to good yields.