Issue 95, 2016
From the journal:

RSC Advances

The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov,*ab   Y. V. Seryotkin,abc   N. A. Tumanov,de   D. Paliwoda,f   M. Hanfland,f   A. V. Kurnosovg  and  E. V. Boldyreva*a  

* Corresponding authors

a Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Str. 18, Novosibirsk 630128, Russia
E-mail: b.zakharov@yahoo.com, eboldyreva@yahoo.com

b Novosibirsk State University, Pirogova Str. 2, Novosibirsk 630090, Russia

c V.S. Sobolev Institute of Geology and Mineralogy SB RAS, Ac. Koptyuga ave. 3, Novosibirsk 630090, Russia

d Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place L. Pasteur 1, Louvain-la-Neuve 1348, Belgium

e Université de Namur, Rue de Bruxelles 61, Namur 5000, Belgium

f European Synchrotron Radiation Facility, Avenue des Martyrs 71, Grenoble 38000, France

g Bayerisches Geoinstitut, Universität Bayreuth, Universitätsstraße 30, Bayreuth D-95447, Germany

Abstract

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1 : 1 pentane–isopentane mixture.

Graphical abstract: The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

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Article information

DOI
https://doi.org/10.1039/C6RA17750F
Article type
Paper
Submitted
12 Jul 2016
Accepted
21 Sep 2016
First published
21 Sep 2016
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2016,6, 92629-92637

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The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov and E. V. Boldyreva, RSC Adv., 2016, 6, 92629 DOI: 10.1039/C6RA17750F

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