Issue 17, 2017, Issue in Progress
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RSC Advances

Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds†

Yu Gao, ORCID logo ‡a   Ammar Mansoor Hassanbhai,‡b   Jing Lim,‡b   Lianhui Wang*a  and  Chenjie Xu*bc  

* Corresponding authors

a Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamlhwang@njupt.edu.cn

b School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457
E-mail: cjxu@ntu.edu.sg

c NTU-Northwestern Institute for Nanomedicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798

Abstract

This work investigated the antimicrobial activity of Ag octahedral nanoparticle containing polycaprolactone scaffolds (Ag–PCL) that is fabricated via cryomilling. The fabricated composite scaffolds exhibited localized antibacterial activity with no adverse effects on viability and osteogenic differentiation of human fetal mesenchymal stem cells (hfMSCs). Compared to plain PCL scaffolds, the Ag–PCL scaffolds significantly reduce bacteria survival to 32.2% over a 4 hour incubation.

Graphical abstract: Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds

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Article information

DOI
https://doi.org/10.1039/C6RA26063B
Article type
Paper
Submitted
31 Oct 2016
Accepted
30 Jan 2017
First published
06 Feb 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 10051-10056

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Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds

Y. Gao, A. M. Hassanbhai, J. Lim, L. Wang and C. Xu, RSC Adv., 2017, 7, 10051 DOI: 10.1039/C6RA26063B

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