Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational E ⇆ Z interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E-conformer and substitution in the 4th position of the isatin core stabilizing the Z-form.
A. S. Smirnov, D. N. Nikolaev, V. V. Gurzhiy, S. N. Smirnov, V. S. Suslonov, A. V. Garabadzhiu and P. B. Davidovich, RSC Adv., 2017, 7, 10070 DOI: 10.1039/C6RA26779C
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