Issue 6, 2017, Issue in Progress
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RSC Advances

Effective gene-silencing of siRNAs that contain functionalized spacer linkages within the central region†

Jean-Paul Desaulniers, ORCID logo *a   Gordon Hagen,a   Jocelyn Anderson,a   Chris McKima  and  Blake Robertsa  

* Corresponding authors

a University of Ontario Institute of Technology, Faculty of Science, 2000 Simcoe Street North, Oshawa, ON L1H 7K4, Canada
E-mail: Jean-Paul.Desaulniers@uoit.ca

Abstract

Short-interfering RNAs containing a variety of functional groups at the central region of the sense strand were synthesized and evaluated. The gene-silencing data suggest that these siRNAs are biocompatible and are very effective in cell-based assays.

Graphical abstract: Effective gene-silencing of siRNAs that contain functionalized spacer linkages within the central region

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Article information

DOI
https://doi.org/10.1039/C6RA27701B
Article type
Paper
Submitted
02 Dec 2016
Accepted
20 Dec 2016
First published
13 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 3450-3454

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Effective gene-silencing of siRNAs that contain functionalized spacer linkages within the central region

J. Desaulniers, G. Hagen, J. Anderson, C. McKim and B. Roberts, RSC Adv., 2017, 7, 3450 DOI: 10.1039/C6RA27701B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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