Issue 12, 2017, Issue in Progress

Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

Abstract

An efficient three-component tandem cyclization reaction for the synthesis of highly substituted oxazolidines was achieved through the Pd0-catalyzed cyclization of buta-2,3-dien-1-ol with aryl iodides and imines. A range of R1 and R2 functional groups is well-tolerated while affording cyclization products in moderate yields and with moderate to high diastereoselectivities.

Graphical abstract: Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
06 Nov 2016
Accepted
07 Dec 2016
First published
23 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 7401-7405

Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

Y. Hou, M. Qin, X. Yang, Q. Shen, Y. Zhao, Y. Liu and P. Gong, RSC Adv., 2017, 7, 7401 DOI: 10.1039/C6RA27993G

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