Issue 7, 2016

Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

Abstract

We have developed a theranostic nanocomposite of metallic nanoparticles that uses two distinct fluorescence mechanisms: Förster Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) controlled by ligand–receptor interaction. Supramolecular assembly of the fluorophore-labeled glycoligands to cyclodextrin-capped gold nanoparticles produces a nanocomposite with a quenched fluorescence due to FRET from the fluorophore to the proximal particle. Subsequently, interaction with a selective protein receptor leads to an aggregation of the composite, reactivating the fluorescence by MEF from the distal metallic particles to fluorophores encapsulated in the aggregates. The aggregation also causes a red-shift in absorbance of the composite, thereby enhancing the production of reactive oxygen species (ROS) on red-light irradiation. Our nanocomposite has proven suitable for targeted cancer cell imaging as well as multimode therapy using both the photodynamic and drug delivery properties of the composite.

Graphical abstract: Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Apr 2016
Accepted
03 May 2016
First published
04 May 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 4004-4008

Author version available

Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

X. Hu, Y. Zang, J. Li, G. Chen, T. D. James, X. He and H. Tian, Chem. Sci., 2016, 7, 4004 DOI: 10.1039/C6SC01463A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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