Issue 3, 2017

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

Abstract

The generation of antibody conjugates with a loading of two modules is desirable for a host of reasons. Whilst certain antibody engineering approaches have been useful in the preparation of such constructs, a reliable method based on a native antibody scaffold without the use of enzymes or harsh oxidative conditions has hitherto not been achieved. The use of native antibodies has several advantages in terms of cost, practicality, accessibility, time and overall efficiency. Herein we present a novel, reliable method of furnishing antibody conjugates with a loading of two modules starting from a native antibody scaffold.

Graphical abstract: Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

Supplementary files

Article information

Article type
Edge Article
Submitted
15 Aug 2016
Accepted
24 Nov 2016
First published
28 Nov 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 2056-2060

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

M. T. W. Lee, A. Maruani, D. A. Richards, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2017, 8, 2056 DOI: 10.1039/C6SC03655D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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